Basic Sciences/Laboratory
Immune Activation in Virologically Suppressed Indian HIV- Infected Patients: The objective of this study is to determine the size of virus reservoir and level of residual viral replication in CD4 T-cells of patients on suppressive ART.
PRINCIPAL INVESTIGATORS
Dr. S.Saravanan.
PROJECT SUMMARY
DURATION
2013-2015 (2 Years).
FUNDING SOURCE
Indian Council for Medical Research (New Delhi) and National Institutes of Health (USA).
COLLABORATING INSTITUTIONS
University of Miami (USA).
HIV Drug Resistance Monitoring in Chennai, India.
PRINCIPAL INVESTIGATORS
Dr. S. Saravanan.
PROJECT SUMMARY
DURATION
2013-2015 (2 Years).
FUNDING SOURCE
Indian Council for Medical Research (New Delhi) and National Institutes of Health (USA).
COLLABORATING INSTITUTIONS
Brown University (USA) & Stanford University (USA).
Validating the Cost-Effective Pooling HBV DNA PCR for detecting Occult HBV among HIV-1 patients.
PRINCIPAL INVESTIGATORS
Dr. S. Saravanan.
PROJECT SUMMARY
DURATION
2012-2014 (2 Years).
FUNDING SOURCE
Indian Council for Medical Research (New Delhi) and National Institutes of Health (USA).
COLLABORATING INSTITUTIONS
University of California (USA).
Validation Study of ReaSLR Sputum Concentration Method for AFB Microscopy.
PRINCIPAL INVESTIGATORS
Dr.R.Vignesh.
PROJECT SUMMARY
DURATION
2012 (1 Year).
FUNDING SOURCE
Reametrix PVT Ltd (Bangalore).
COLLABORATING INSTITUTIONS
Nil
Drug Resistance in Different HIV-1 Subtypes.
PRINCIPAL INVESTIGATORS
Dr. S.Saravanan.
PROJECT SUMMARY
DURATION
2011-2014 (3 Years).
FUNDING SOURCE
National Institutes of Health (USA).
COLLABORATING INSTITUTIONS
Brown University (USA) and Stanford University (USA).
Changes in Mitochondrial DNA as a marker of Nucleoside Toxicity among HIV-Infected individuals in Southern India.
PRINCIPAL INVESTIGATORS
Dr. P. Balakrishnan.
PROJECT SUMMARY
DURATION
2011-2014 (3 Years).
FUNDING SOURCE
Indian Council for Medical Research (New Delhi).
COLLABORATING INSTITUTIONS
Nil
A Cross-Sectional Study to Screen Neutralizing Monoclonal Antibodies (Protocol G).
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon/ Dr. K.G.Murugavel (Coordinator)
PROJECT SUMMARY
DURATION
2011-2014 (3 Years).
FUNDING SOURCE
Department of Biotechnology (New Delhi).
COLLABORATING INSTITUTIONS
The International AIDS Vaccine Initiative (New Delhi).
Immunological correlates of Lack of Disease progression in HIV-1 subtype C Infected Long Term Non-Progressors (LTNP) from India.
PRINCIPAL INVESTIGATORS
Dr. K.G.Murugavel.
PROJECT SUMMARY
DURATION
2011-2014 (3 Years).
FUNDING SOURCE
Indian Council for Medical Research (New Delhi).
COLLABORATING INSTITUTIONS
Nil
HIV Vaccine Immunogen Design: Identification of T-cell epitopes associated with control of viral replication in Indian and South African HIV-1 infected individuals (IAVI INDO-SA Project).
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon/ Dr. K.G.Murugavel (Site Coordinator)
PROJECT SUMMARY
DURATION
2011-2012 (1 Year).
FUNDING SOURCE
Department of Science & Technology (New Delhi).
COLLABORATING INSTITUTIONS
The International AIDS Vaccine Initiative (New Delhi), Jawaharlal Nehru Centre for Advanced Scientific Research (Bengaluru), All India Institute of Medical Science (New Delhi) and National AIDS Research Institute (Pune).
Evaluation of AlereTM DetermineTM TB LAM AG Rapid Test for Diagnosis of TB Infection.
PRINCIPAL INVESTIGATORS
Dr.R.Vignesh.
PROJECT SUMMARY
DURATION
2011 (1 Year).
FUNDING SOURCE
Alere-India (New Delhi).
COLLABORATING INSTITUTIONS
Nil
HIV-1 Pol Gene Diversity among Patients on Antiretroviral Therapy.
PRINCIPAL INVESTIGATORS
Ms.S.Sivamalar.
PROJECT SUMMARY
DURATION
2010-2015 (5 Years).
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil.
Development of Anti-Viral Micro RNA Based Prognostic Biomarker for HIV-1 Infection – A Pilot Study.
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon.
PROJECT SUMMARY
DURATION
2010-2012 (2 Years).
FUNDING SOURCE
Council of Scientific and Industrial Research (New Delhi).
COLLABORATING INSTITUTIONS
Institute of Genomics & Integrative Biology (New Delhi).
Immunological correlates of immune reconstitution inflammatory syndrome (IRIS) in subjects with HIV-1/tuberculosis co-infection after initiating highly active anti-retroviral therapy.
PRINCIPAL INVESTIGATORS
Dr. K.G.Murugavel.
PROJECT SUMMARY
DURATION
2010-2013 (3 Years).
FUNDING SOURCE
Indian Council for Medical Research (New Delhi).
COLLABORATING INSTITUTIONS
Nil
Protease Inhibitors Drug Resistance In HIV-1 Infected Patients Who Are Failing With Second Line HAART.
PRINCIPAL INVESTIGATORS
Dr.S.Saravanan.
PROJECT SUMMARY
DURATION
2010-2012 (1 Year).
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil
Evaluation of Host Immune Responses to the Tat Antigen of HIV-1 in the Indian Clinical Cohorts.
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon.
PROJECT SUMMARY
DURATION
2009-2012 (3 Years).
FUNDING SOURCE
Department of Biotechnology (New Delhi).
COLLABORATING INSTITUTIONS
Jawaharlal Nehru Centre for Advanced Scientific Research (Bangalore).
Correlates of Mucosal HIV-transmission in Indian Women.
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon
PROJECT SUMMARY
DURATION
2009-2012 (3 Years).
FUNDING SOURCE
National Institutes of Health (USA) (Grant # R03 A1062420).
COLLABORATING INSTITUTIONS
UC Davis (USA), Brown University (USA) and Rush University (USA
Implementation of MODS for TB and MDR-TB Control: Towards Sustainable Rollout
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon.
PROJECT SUMMARY
DURATION
2009-2012 (3 Years).
FUNDING SOURCE
The World Bank Development Market Place (USA).
COLLABORATING INSTITUTIONS
Universidad Peruana Cayetano Heredia (Peru).
Dried Blood Spots (DBS) versus Peripheral Plasma for Quantitation of HIV-1 RNA and Genotyping in HIV-Infected South Indian Patients.
PRINCIPAL INVESTIGATORS
Dr. Vidya Madhavan.
PROJECT SUMMARY
DURATION
2009-2010 (1 Year).
FUNDING SOURCE
Intra-mural
COLLABORATING INSTITUTIONS
Brown University (USA).
Ancillary Studies to Contribute to the Overall Goals of the Global HIV/AIDS Vaccine Enterprise (GHAVE) Comprehensive Antibody Vaccine Immune Monitoring Consortium (GCAV) for AIDS Vaccine Discovery Program.
PRINCIPAL INVESTIGATORS
Dr. P.Balakrishnan.
PROJECT SUMMARY
DURATION
2008-2012 (5 Years).
FUNDING SOURCE
Bill & Melinda Gates Foundation (USA).
COLLABORATING INSTITUTIONS
Duke University (USA).
Determination of Reference Ranges for CD4+, CD8+ & CD3+ T cell counts and percentages for adult Indian population – A Multisite Study.
PRINCIPAL INVESTIGATORS
Dr.P.Balakrishnan.
PROJECT SUMMARY
DURATION
2009-2010 (1 Year).
FUNDING SOURCE
National AIDS Control Organization (New Delhi).
COLLABORATING INSTITUTIONS
Postgraduate Institute of Medical Education and Research (Chandigarh), National Institute of Mental Health and Neurosciences (Bengaluru), All India Institute of Medical Science (New Delhi) and National AIDS Research Institute (Pune).
Genetic Basis for HIV-1 Transmission, Resistance and Disease Progression: Polymorphism in MHC, Chemokine / Cytokine and their Receptor Genes.
PRINCIPAL INVESTIGATORS
Prof. Suniti Solomon.
PROJECT SUMMARY
DURATION
2008-2010 (3 Years).
FUNDING SOURCE
Department of Biotechnology (New Delhi).
COLLABORATING INSTITUTIONS
National Institute for Research in Tuberculosis (Chennai), National AIDS Research Institute (Pune) and All India Institute of Medical Science (New Delhi).
Drug Resistance in plasma and genital tract in south India.
PRINCIPAL INVESTIGATORS
Dr. S.Saravanan.
PROJECT SUMMARY
DURATION
2007-2008 (1 Year).
FUNDING SOURCE
Lifespan/Tufts/Brown Center for AIDS Research (USA).
COLLABORATING INSTITUTIONS
Brown University (USA) & Stanford University (USA).
Evaluation of low-cost methodology to quantify HIV-1 viral load.
PRINCIPAL INVESTIGATORS
Dr.H.Syed Iqbal.
PROJECT SUMMARY
DURATION
2006-2007 (1 Year).
FUNDING SOURCE
CAVIDI (Sweden
COLLABORATING INSTITUTIONS
Burnet Institute for Medical Research and Public Health (Australia).
Immunological studies to elucidate the immunopathogenesis of TB-associated IRIS.
PRINCIPAL INVESTIGATORS
Dr. R. Vignesh.
PROJECT SUMMARY
DURATION
2005-2010 (5 Years).
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Brown University (USA) and University of Western Australia (Australia).
Immunological studies to understand the cellular immunity among HIV infected.
PRINCIPAL INVESTIGATORS
Dr.K.G.Murugavel.
PROJECT SUMMARY
DURATION
2005-2009 (4 Years).
FUNDING SOURCE
Emory CFAR Grant (USA).
COLLABORATING INSTITUTIONS
Emory University (USA).
valuation of HIV Test for Diagnosis of HIV Infection.
PRINCIPAL INVESTIGATORS
Dr.H.Syed Iqbal.
PROJECT SUMMARY
DURATION
2005-2008 (3 Years).
FUNDING SOURCE
Span Diagnostics Ltd (Surat) and Premier Medical Corporation (Goa)
COLLABORATING INSTITUTIONS
Nil
Drug Resistance, Polymorphisms and phylogenetic analysis of HIV-1 pol gene from injecting drug users and VCT clients in Chennai.
PRINCIPAL INVESTIGATORS
Dr. Syed Hussain Iqbal.
PROJECT SUMMARY
DURATION
2005-2009 (5 Years).
FUNDING SOURCE
Intra-mural
COLLABORATING INSTITUTIONS
Nil
Genotypic HIV-1 Drug Resistance among patients failing anti-retroviral therapy in South India.
PRINCIPAL INVESTIGATORS
Dr.Vidya Madhavan.
PROJECT SUMMARY
DURATION
2005-2009 (5 Years).
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil
Genetic diversity of HIV 1 gag and pol sequences in sero-concordant couples.
PRINCIPAL INVESTIGATORS
Dr. Uma Shanmugasundaram.
PROJECT SUMMARY
DURATION
2005-2009 (5 Years).
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil
Bio- chemical changes among persons with HIV disease in Southern India.
PRINCIPAL INVESTIGATORS
Dr. Sundaram Muthu.
PROJECT SUMMARY
DURATION
2005-2009 (5 Years).
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil.
An Evaluation of Guava AutoCD4% Assay for Monitoring HIV-infected Individuals in Resource-limited Settings.
PRINCIPAL INVESTIGATORS
Dr.P.Balakrishnan.
PROJECT SUMMARY
DURATION
2005-2006 (1 Year)
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil
Establishment of Normal Ranges for immunohematological and biochemistry parameters using healthy volunteers.
PRINCIPAL INVESTIGATORS
Dr.P.Balakrishnan
PROJECT SUMMARY
DURATION
2005-2006 (1 Year)
FUNDING SOURCE
Intra-mural.
COLLABORATING INSTITUTIONS
Nil.
Evaluation of a novel CD4 assay using an ordinary microscopy to monitor HIV-infected persons in South India.
PRINCIPAL INVESTIGATORS
Dr.P.Balakrishnan
PROJECT SUMMARY
An inexpensive, simple, and manual method of CD4 T-cell quantitation in HIV-infected individuals for use in developing countries. Balakrishnan P, Dunne M, Kumarasamy N et al. Journal of acquired immune deficiency syndromes (1999). 2004; 36(5):1006-10.PMID: 15247552
DURATION
2002-2003 (1 Year).
FUNDING SOURCE
Beckman Coulter (USA).
COLLABORATING INSTITUTIONS
Burnet Institute for Medical Research and Public Health (Australia).