Dr. P.Balakrishnan / Dr.R.Vignesh

The YRG CARE TB laboratory, as a Regional TB Diagnostic Laboratory will perform protocol-mandated TB diagnostic assays and serve as a regional/reference laboratory for providing support to the scientific agendas in TB research and TB therapeutic agenda of the ACTG/IMPAACT/HVTN.

2012-2018 (7 Years)

National Institutes of Health (USA)

Nil

Dr. S. Saravanan.

To evaluate the test performance characteristics of the pooling strategy of the samples for nucleic acid testing (NAT) and drug resistance (DR) genotyping when monitoring patients for virologic failure during first-line ART.

2014-2016 (2 Years)

Department of Biotechnology (New Delhi)

University of California (USA)

Dr.KG. Murugavel

To study the phenotypic characteristics of T-cells and its association with disease non-progression in HIV infected long-term non-progressors from South India. HIV-1 humoral immune responses among HIV-1 subtype-C infected individuals & Preparedness for enrolling Acute/Primary HIV cases.

2014-2016 (2 Years)

IAVI (IAVI Grant Number: 2104)

The International AIDS Vaccine Initiative (New Delhi) and HIV Vaccine Translational Research Laboratory (Gurgaon)

Dr. P.Balakrishnan

This study involves an evaluation of a novel POC CD4 assay (VISITECT® CD4 assay – developed by Burnet Institute, Australia will be evaluated in comparison with a standard flow cytometry assay both in a laboratory and two field settings.

2014-2017 (4 Years)

Omega Diagnostics (Mumbai)

Nil

Dr. H.Syed Iqbal.

This protocol serves as a framework for the collection and storage of sputum, serum, urine, PBMCs, host mRNA and DNA, and other biological specimens for biobanking in a central repository to be used in laboratory studies to evaluate candidate biomarkers of TB treatment response.

2016-2018 (2 Years)

National Institutes of Health (USA)

Nil

Dr. S. Saravanan.

This study aimed to determine the cause for poor T-cell recovery among immunological non-responders (INR) by scrutinizing various facets involved in T-cell exhaustion.

2016-2019 (3 Years).

Council of Scientific and Industrial Research (New Delhi).

Nil

Dr.P.Balakrishnan.

The study is to examine the profile of HIV-1 subtype-C pathogenesis in India at four different clinics in four different cities. We recently identified that several novel strains of subtype-C have been evolving and spreading in India over the past decade replacing the standard subtype-C viruses.

2016-2020 (5 Years).

Department of Biotechnology (New Delhi).

Jawaharlal Nehru Centre for Advanced Scientific Research (Bangalore) and National AIDS Research Institute (Pune).

Dr. K.G.Murugavel.

This proposal is to build the cohorts for ESN and LTNPs/ECs (adult and pediatric) through the establishment of a consortium of institutions of national significance. Additionally the consortium propose to create a repository of biological samples that could be extremely useful for future studies aimed at answering emerging questions on virus control.

2016-2020 (5 Years).

Department of Biotechnology (New Delhi) and Indian Council of Medical Research (New Delhi).

National Institute for Research in Tuberculosis (Chennai), National Institute of Epidemiology (Chennai) and National Institute of Immunology (New Delhi).