The Sabrang Clinic stands as a pioneering effort aimed at providing holistic healthcare services to transindividuals in Lucknow, Uttar Pradesh, India. This innovative initiative aims to address the unique healthcare needs of transindividuals who often face challenges and discrimination when seeking medical care. The clinic provides a safe and inclusive environment, free from prejudice and stigmatization, where transindividuals can access a wide range of services. The project activities include supporting enhanced peer outreach to identify gaps in the HIV continuum of care, estimating key population size and distribution to inform quality improvement activities, and implementing and assessing prevention and differentiated ART delivery strategies. The project is guided by evidence-based practices that are aimed at improving the HIV cascade to achieve 95-95-95 targets. Sincere appreciation for the UPSACS officials who were the driving force behind this intervention.