Clinical Studies

YRGCARE Collaborates with the Division of Infectious Diseases, Miriam Hospital, Brown University and studies the spectrum of HIV disease and the Natural History of HIV disease in Southern India through the Fogarty program of Brown University.

Other ongoing projects with Brown University:

  • Usage of generic antiretroviral therapy in Indian setting
  • Reliability, validity and acceptability of assessment of adherence to Antiretroviral Treatment in Chennai
  • Fat redistribution syndrome following HAART
  • ARV Resistance studies
  • A Randomized Controlled clinical trial of Structured Intermittent HAART Therapy (SIT) vs. Continuous HAART Therapy in HIV-positive patients in South India.
  • HBV, HCV co-infection in persons attending HIV VCT services
  • Prevalence and Incidence of STIs of HIV negative men attending STD clinic of Govt. Hospital and sero-negative wives of HIV infected male patients attending VHS-YRGCARE.

YRGCARE collaborates with Sankara Nethralaya and studies the Ophthalmic manifestations in persons with HIV disease.

Through a collaboration with Ragas Dental College ,Oral manifestations in persons with HIV are documented.

YRGCARE is one of the sites of HIV Prevention Trial Network (HPTN) of National Institutes of Health, USA (NIH). Under this network YRGCARE is involved in the following studies:

  • HPTN033: Incidence of HIV among persons with high-risk behaviour
  • HPTN052: A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy plus HIV Primary care versus HIV Primary Care alone to prevent the sexual transmission of HIV-1 in serodiscordant couples.-HPTN/NIH multisite study (ongoing)

YRGCARE is one of the sites of Adult AIDS Clinical Trial Group (AACTG) of National Institutes of Health, USA (NIH). Under this network YRGCARE is involved in the following study.

ACTG5175: A Phase III, Randomized, Open-Label Evaluation of the Efficacy of Three Nucleoside Reverse Transcriptase Inhibitor Combinations for Initial Antiretroviral Treatment of HIV-1 Infected Persons in Resource-Limited Countries

ACTG5230: A pilot study of Lopinavir/Ritonavir in Participants Experiencing Virology Relapse on NNRTI- Containing Regimens

ACTG5274/Remember: Manual of Procedures and Supplemental Materials (MOPS) .